The gang enters a script-writing competition, where the winning script will get turned into a movie! The director, Quentin Smithee, chooses Jimmy, Cindy, Libby, Sheen, and Carl (much to Hugh's disappointment) to star in Jimmy's movie, which will be shot entirely in Retroville. During the filming, however, dangerous on-set ""accidents"" start to happen, and the rest of the kids start to doubt starry-eyed Jimmy and inexperienced Smithee.

An encounter with the Van Patten radiation belt causes strange mutations in the kids: Jimmy glows orange, Cindy is super strong, Sheen is super fast, Libby can become invisible, and Carl has sonic burps. As the N Men, they work to fight evil in Retroville, but they end up doing more harm than good. The military soon steps in, capturing four of the kids, but only laughing at Jimmy's orange hue. When Jimmy discovers the dark side to his friends' new powers, he must race against time to find a cure - and deal with the effects of his power.

Jimmy, Sheen, and Carl travel 15 years into the future, only to find that some things have gone wrong. Can they right the past to save their future?

After the car company Hugh works for decides they don't need his services anymore, the Neutrons are faced with the awful prospect of moving. To stay in Retroville, Hugh becomes a toy inventor, and the Nanobots return again to wreak more havoc....

A trip gone wrong ends up turning even worse when Jimmy and Cindy get into an argument that winds up getting them stranded together.

Jimmy becomes frustrated at school when his scientific lecture is disregarded in favor of making macaroni sculptures. So, when Dean Cain, head of Pamona University, offers him a chance to enroll in that college to help them win a science grant, Jimmy eagerly accepts. He soon finds, however, that college is a completely different world from elementary school ... a much more challenging one. And when it comes to jealousy of Jimmy's knowledge, Cindy (left behind at Lindbergh Elementary) doesn't hold a candle to new classmate Seymour.

A trip gone wrong ends up turning even worse when Jimmy and Cindy get into an argument that winds up getting them stranded together.

The Evil Beneath Jimmy, Carl and Sheen set out to discover the mystery behind the Bahama Quadrangle. They are captured by a mad scientist who wants to make them into slaves!

Beautiful Gorgeous and Jet Fusion are getting married!

Who's Your Mommy Carl gets infected by a ""face-hugging"" parasite.

A kung-fu warrior wants to be The Chosen One in the temple of Shangri-Llama, but Sheen holds that position, with his ability to put his leg behind his head. So, the warrior kidnaps Libby in order to fight with Sheen and claim the title of The Chosen One as his own.

Jimmy accidentally shrinks the town of Retroville. Can he get it back to normal size before they're crushed?

One of Us Everyone in town is acting strangely, so it's up to Jimmy and Cindy to figure out why and reverse the effects.

Vanishing Act Jimmy tries to become a magician to impress Betty, but something goes horribly wrong, and he ends up transporting the group into alternate universes.

How to Sink a Sub Jimmy sends the teachers away for a week, so the parents decide to step in.

Lady Sings the News The kids become news anchors for a local television network.

Eustace Strych is back, and he's still determined to humiliatingly defeat Jimmy. Now the race to find an energy source on Mars is on! Who will win?

Carl Wheezer, Boy Genius Carl asks Jimmy to help him pretend to be a genius, just for one day, in order to impress a girl. But Jimmy soon wishes he hadn't....

Best in Show Jimmy enters Goddard in a dog show. Goddard easily wins, but he is soon disqualified for being robotic ... so the canine runs away to let Jimmy get a real dog.